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KMID : 0387720150260020123
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Korean Journal of Blood Transfusion
2015 Volume.26 No. 2 p.123 ~ p.131
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Correlation between the Severity of Bone Pain and the Amount of CD34＋ Cells after Peripheral Blood Stem Cell Mobilization
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서지원:Seo Ji-Weon
최지선:Choi Ji-Seon/김양현:Kim Yang-Hyun/윤성수:Yoon Sung-Soo/박선양:Park Seon-Yang/한규섭:Han Kyou-Sup
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Abstract
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Background: Peripheral blood stem cells (PBSCs) are mobilized by granulocyte-colony stimulating factor (G-CSF), which causes several side effects in allogeneic donors. We report on side effects of G-CSF administration and determine which side effects could be used in predicting the amount of harvested CD34＋ cells.
Methods: Data from the first PBSC collections of 155 healthy donors between 2007 and 2010 were analyzed. Side effects were assessed using adverse event inventory, which was graded from 1 (mild) to 3 (severe) or 4 (disabling).
Results: G-CSF administration caused an elevation of WBC counts (mean 44,834/mL) and 86% of them were neutrophils. The mean mononuclear cells in apheresis products was 6.6×108/kg and mean CD34＋ cells was 6.0×106/kg. Bone pain was reported by 151 healthy donors (97%) and severe bone pain was related to more CD34＋ cells in apheresis products (P=0.041): 39 for grade 1 (5.1×106 CD34＋cells/kg), 86 for grade 2 (6.0×106), and 26 for grade 3 (7.1×106). In addition, the percentage of collecting more than 5.0×106 CD34＋cells/kg during the first leukapheresis showed correlation with the severity of bone pain.
Conclusion: Bone pain was the most common side effect of G-CSF mobilization and more CD34＋ cells were harvested in cases of severe bone pain.
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KEYWORD
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Peripheral blood stem cell, Bone pain, G-CSF, CD34 positive cell, Side effect
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